PM333. Transcriptomic immaturity of hippocampus and prefrontal cortex in patients with alcoholism

s | 21 and is a significant comorbid factor for other psychiatric and medical disorders. To date, no medication has been approved by the United States Food and Drug Administration for this indication. In the present Phase 2A, single-site, randomized, double-blind, placebo-controlled clinical trial, we determined the safety/tolerability and efficacy of a combination drug treatment, consisting of an immediate-release methylphenidate formulation (MPh-IR) and a novel formulation of the antiemetic ondansetron (Ond-PR2) ([MPh-IR + Ond-PR2]; ClinicalTrials.gov identifier: NCT01290276). Scores on selected behavioral rating scales and functional neuroimaging assessments under standard cue-reactivity and inhibitory control paradigms were used to compare the [MPh-IR + Ond-PR2] and placebo groups before and after two week treatment. All study procedures were conducted according to a protocol approved by the Duke University Health System Institutional Review Board. A total of 48 subjects meeting the Diagnostic and Statistical Manual of Mental Disorders Version 4 (DSM-4) criteria for “primary substance abuse” were screened and 30 qualifying subjects were randomized into one of the two treatment groups. Twenty eight subject completed the treatment and preand post-treatment assessments. No significant differences were observed between the two groups in the number of subjects experiencing adverse events, and no serious adverse events were observed or reported. In contrast to safety/ tolerability, [MPh-IR + Ond-PR2] treatment significantly reduced or tended to reduce selected rating score and neuroimaging measurements compared to placebo treatment. In summary, [MPh-IR + Ond-PR2] treatment was safe and well-tolerated by abstinent psychostimulant abusers, and the results to date indicate that this treatment might provide for an effective option for psychostimulant abuse treatment. PM331 Associations between self control, smoking, alcohol drinking, internet, smartphone addiction among South Korean Adolescents Seung Gon Kim, MD, PhD1, Sang Hoon Kim, MD, PhD1, Sang Hag Park, MD, PhD1, IL Han Choo, MD, PhD1 1Department of Psychiatry, College of Medicine, Chosun University, Gwangju, Republic of Korea Abstract Objectives: The purpose of this study was to examine the associations between self control, smoking, alcohol drinking, internet, smartphone addiction among a sample of South Korean middle school students. Methods: An epidemiologic survey was conducted in a sample of 1,852 students (grades 7 through 9) from five middle schools in Gwangju, South Korea. We obtained data using a self reported questionnaire asking about demographic information, self control, smoking, alcohol drinking, internet, smartphone addiction. Our final analytical sample was 1,629 cases with complete information, after deleting the cases with missing values. Results: A standard deviation increase in low self-control, the expected count of students’ drinking increases by 64.2%. With regard to smoking, a standard deviation increase in low selfcontrol equates to a 189.9% increase in the expected count of students’ smoking. In the Internet addiction model, the magnitude of the effect of low self-control (β = .21) was far greater than that for peer delinquency (.03) and attachment to parents (-.09). The low self-control scale accounted for 35% of the total explained variance in Internet addiction. In smartphone addiction model, low self-control demonstrates the greatest magnitude of the standardized regression coefficient (.28) among all predictors, accounting for 39% of the total variance explained by the model. Conclusion: Our findings show that low self-control is a significant predictor of alcohol drinking, smoking, internet and smartphone addiction even when accounting for peer influences, parental attachment, and other statistical controls. Future research is needed about association between self control and deviant or addictive analogous behaviors.